![]() ![]() It follows that SAMe plays an important role in the prevention of diseases related to altered genetic and neurotransmitter profiles including depression, anxiety, and MTHFR gene mutation. ![]() 8 Adequate levels of SAMe and folate must be maintained for proper DNA, protein, and neurotransmitter production. Without the participation of 5-MTHF in this process, SAMe and neurotransmitter levels decrease in the cerebrospinal fluid. ![]() 7 SAMe, the downstream metabolite of methionine, is involved in numerous biochemical methyl donation reactions, including reactions forming monoamine neurotransmitters. In a patient with MTHFR mutation(s), the active metabolite of folate, 5-methyltetrahydrofolate (5-MTHF), participates in the remethylation of homocysteine to create methionine at a reduced rate. 6 These studies suggest potential clinical relevance beyond controlling homocysteine levels for heterozygous MTHFR individuals. 4, 5 Another study indicates that a compound heterozygous patient may even encounter additional complications beyond that of a homozygous C677T patient. 2, 3 The British Women’s Heart and Health study and a meta-analysis found evidence for intermediate risk of depression (closely related to anxiety) for individuals with heterozygous mutations. 3 Even though heterozygous mutations impair the regulation of homocysteine, adequate folate levels are believed to “cancel out” this defect. 1 Compound heterozygous MTHFR mutations are less well understood and are not generally believed to be clinically relevant. The frequency of the C677T polymorphism of MTHFR in the Caucasian population is 12% homozygous and up to 50% heterozygous. The most common MTHFR mutation is the MTHFR C677T mutation. They play a suspected role in several physiologic symptoms-including anxiety. MTHFR mutations, for which at least 24 known genetic polymorphisms have been identified, are associated with metabolic dysfunction. Great awareness of the effects of B-vitamin supplementation in the context of varied heterozygous MTHFR mutations could be useful in clinical practice. It is also a transporter of the antioxidant mineral, selenium.This case outlines the challenges in treatment and the potential for improvements in the management of individuals with MTHFR gene mutations. It contributes to the synthesis of S-adenosyl-Lmethionine (SAMe), which is necessary for normal brain function, and L-cysteine, which is a component of glutathione, an important antioxidant molecule in the body. L-Methionine is an essential free-form amino acid. Better cognitive thinking, reasoning, spatial and abstract reasoning may be improved by consuming green coffee bean extracts on a daily basis. Research shows that green coffee beans have the ability to enhance learning abilities and analytic reasoning skills. (ATP serves as the major energy source for cells throughout the body).Ĭonsuming Green Coffee Bean Extract on a regular basis may improve or enhance brain activity greatly leading to better concentration and attention span. ![]() It is produced by the body from ATP and the amino acid methionine. Being deficient in either vitamin B12 or folate may reduce levels of SAMe in your body. It works in conjunction vitamin B12 and folate (vitamin B9). SAMe plays a role in the immune system, maintains cell membranes, and helps produce and break down brain chemicals, such as serotonin, melatonin, and dopamine. S-Adenosylmethionine (SAMe) is a naturally occurring compound that is found in almost every tissue and fluid in the body. These donors serve to methylate dopamine and make it easier to break down (I.E. This formula consists of many forms of “methyl” donors, such as L-taurine, L-methionine and SAMe. Max Focus consists of 10 ingredients carefully formulated by our advising physicians to work together and maximize each ingredient’s full potential. ![]()
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